FPR3 Antibody

Catalog Number:

37576

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P25089
NCBI Gene ID: 2359
Gene Accssion: NP_002021

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human formyl peptide receptor 3

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total FPR3 protein.

Applications:

IHC

Background:

The N-formyl peptide receptor (FPR) family is comprised of three members, FPR, FPR3 (also designated FPRL1, lipoxin A4 receptor, FPRH1 or FPR2) and FPR like-2 (FPRL2), all of which are chemotactic G protein-coupled receptors that contain seven transmembrane domains. These receptors are found on the surface of phagocytic leukocytes, such as neutrophils and monocytes, and each family member contains specific residues, which are responsible for determining its ligand specificity. FPR3 is a promiscuous receptor that binds to several ligands, including lipoxin A4, N-formyl-methionyl-leucyl-phenylalanine (fMLP), serum amyloid A (SAA), prion peptide and the 42 amino acid form of beta amyloid. Upon activation, FPR3 induces migration and calcium mobilization in human monocytes and neutrophils and is involved in inflammatory and host defense responses. FPR3 may mediate inflammation in prion and Alzheimer¡¯s diseases, which makes it a potential target for therapeutic agents.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF