EP300 Antibody

Catalog Number:

37550

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q09472
NCBI Gene ID: 2033
Gene Accssion: NP_001420

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human E1A binding protein p300

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total EP300 protein.

Applications:

IHC

Background:

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF