EIF4G1 Antibody

Catalog Number:

37544

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q04637
NCBI Gene ID: 1981
Gene Accssion: NP_004944

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human eukaryotic translation initiation factor 4 gamma, 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total EIF4G1 protein.

Applications:

IHC

Background:

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.?

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF