CR1 Antibody

Catalog Number:

37501

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P17927
NCBI Gene ID: 1378
Gene Accssion: NP_000564

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human complement component (3b/4b) receptor 1 (Knops blood group)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CR1 protein.

Applications:

IHC

Background:

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF