CENPF Antibody

Catalog Number:

37483

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P49454
NCBI Gene ID: 1063
Gene Accssion: NP_057427

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human centromere protein F, 350/400kDa

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CENPF protein.

Applications:

IHC

Background:

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF