CDK11A/CDK11B Antibody

Catalog Number:

37479

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P21127
NCBI Gene ID: 984
Gene Accssion: NP_277021

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human cyclin-dependent kinase 11A/B

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CDK11A/CDK11B protein.

Applications:

WB IHC

Background:

Cyclin-dependent kinases (CDKs)?are a family of?protein?kinases?first discovered for their role in regulating the?cell cycle. They are also involved in regulating?transcription, mRNA processing, and the differentiation of nerve cells. They are present in all known?eukaryotes, and their regulatory function in the?cell cycle?has been evolutionarily conserved. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase. CDKs phosphorylate their substrates on serines and threonines, so they are serine-threonine kinases.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Datasheet PDF