NOD2 Antibody

Catalog Number:

37460

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9HC29
NCBI Gene ID: 64127
Gene Accssion: NP_071445

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human nucleotide-binding oligomerization domain containing 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NOD2 protein.

Applications:

IHC

Background:

This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF