BLNK Antibody

Catalog Number:

37442

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8WV28
NCBI Gene ID: 29760
Gene Accssion: NP_001107566

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human B-cell linker

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total BLNK protein.

Applications:

IHC

Background:

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia.?

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF