SH2B2 Antibody

Catalog Number:

37426

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O14492
NCBI Gene ID: 10603
Gene Accssion: NP_066189

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human SH2B adaptor protein 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SH2B2 protein.

Applications:

IHC

Background:

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF