SNCA Antibody

Catalog Number:

37420

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P37840
NCBI Gene ID: 6622
Gene Accssion: NP_000336

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human synuclein, alpha (non A4 component of amyloid precursor)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SNCA protein.

Applications:

IHC

Background:

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF