SCNN1A Antibody

Catalog Number:

37412

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P37088
NCBI Gene ID: 6337
Gene Accssion: NP_001029

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human sodium channel, non-voltage-gated 1 alpha subunit

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SCNN1A protein.

Applications:

IHC

Background:

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF