L1CAM Antibody

Catalog Number:

37403

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P32004
NCBI Gene ID: 3897
Gene Accssion: NP_000416

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human L1 cell adhesion molecule

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total L1CAM protein.

Applications:

IHC

Background:

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF