LIN28B Antibody

Catalog Number:

37362

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q6ZN17
NCBI Gene ID: 389421
Gene Accssion: NP_001004317

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human LIN28B

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total LIN28B protein.

Applications:

WB

Background:

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

References:

appl_detail:

Western blotting: 1:500-1:2000

Datasheet PDF