MANF Antibody

Catalog Number:

37346

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P55145
NCBI Gene ID: 7873
Gene Accssion: NP_006001

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human mesencephalic astrocyte-derived neurotrophic factor

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MANF protein.

Applications:

IHC

Background:

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.

References:

appl_detail:

Immunohistochemistry: 1:100-1:300

Datasheet PDF