NUAK1 Antibody

Catalog Number:

37345

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O60285
NCBI Gene ID: 9891
Gene Accssion: NP_055655

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human NUAK family, SNF1-like kinase, 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NUAK1 protein.

Applications:

IHC

Background:

NUAK family SNF1-like kinase 1?also known as?AMPK-related protein kinase 5?(ARK5) is an?enzyme?that in humans is encoded by the?NUAK1?gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF