FAT4 Antibody

Catalog Number:

37293

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q6V0I7
NCBI Gene ID: 79633
Gene Accssion: NP_078858

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human FAT tumor suppressor homolog 4 (Drosophila)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total FAT4 protein.

Applications:

IHC

Background:

FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by γ?secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane?associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF