C12orf5 Antibody

Catalog Number:

37280

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NQ88
NCBI Gene ID: 57103
Gene Accssion: NP_065108

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human chromosome 12 open reading frame 5

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total C12orf5 protein.

Applications:

IHC

Background:

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

References:

appl_detail:

Immunohistochemistry: 1:100-1:300

Datasheet PDF