TEK Antibody

Catalog Number:

37274

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q02763
NCBI Gene ID: 7010
Gene Accssion: NP_000450

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human TEK tyrosine kinase, endothelial

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TEK protein.

Applications:

IHC

Background:

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF