PMS2 Antibody

Catalog Number:

37216

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P54278
NCBI Gene ID: 5395
Gene Accssion: NP_000526

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PMS2 protein.

Applications:

IHC

Background:

This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF