NCR2 Antibody

Catalog Number:

37472

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O95944
NCBI Gene ID: 9436
Gene Accssion: NP_001186438

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human natural cytotoxicity triggering receptor 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NCR2 protein.

Applications:

IHC

Background:

Natural cytotoxicity triggering receptor 2?is a?protein?that in humans is encoded by the?NCR2?gene. NCR2 has also been designated as?CD336?(cluster of differentiation?336). NKp44 is a natural cytotoxicity receptor that is is expressed on IL-2-activated human NK cells and may contribute to the increased efficiency of NK cells to mediate tumor cell lysis. NKp44 is composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. Prolactin up-regulates and cortisol down-regulates the surface expression of NKp44 at the transcriptional level. A cellular ligand for NKp44 (NKp44L) is expressed during HIV-1 infection and is correlated with the progression of CD4+ T cell depletion and an increase of viral load.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF