MDC1 Antibody

Catalog Number:

37181

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q14676
NCBI Gene ID: 9656
Gene Accssion: NP_055456

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human Mediator of DNA-damage checkpoint 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MDC1 protein.

Applications:

IHC

Background:

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

References:

appl_detail:

Immunohistochemistry: 1:100-1:300

Datasheet PDF