SPAG6 Antibody

Catalog Number:

37162

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O75602
NCBI Gene ID: 9576
Gene Accssion: NP_036575

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human sperm associated antigen 6

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SPAG6 protein.

Applications:

WB

Background:

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm.

References:

appl_detail:

Western blotting: 1:200-1:1000

Datasheet PDF