CDH5 Antibody

Catalog Number:

37156

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P33151
NCBI Gene ID: 1003
Gene Accssion: NP_001786

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human cadherin 5, type 2 (vascular endothelium)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CDH5 protein.

Applications:

IHC

Background:

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF