BFAR Antibody

Catalog Number:

37153

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NZS9
NCBI Gene ID: 51283
Gene Accssion: NP_057645

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human bifunctional apoptosis regulator

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total BFAR protein.

Applications:

IHC

Background:

A novel protein, BAR, for bifunctional apoptosis regulator, contains domains that enable it to interact with components of both major apoptosis pathways, where it negatively regulates apoptotic signaling. Like the other anti-apoptosis proteins Bap31 and FLIP, BAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. In addition, BAR contains a domain that also enables it to interact with the mitochondrial Bcl-2 family of proteins. The presence of these various RING, SAM, DED and TM domains suggests that BAR may serve as a scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF