LATS2 Antibody

Catalog Number:

37128

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9NRM7
NCBI Gene ID: 26524
Gene Accssion: NP_055387

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human large tumor suppressor kinase 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total LATS2 protein.

Applications:

IHC

Background:

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF