SMURF2 Antibody

Catalog Number:

37124

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9HAU4
NCBI Gene ID: 64750
Gene Accssion: NP_073576

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human SMAD specific E3 ubiquitin protein ligase 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SMURF2 protein.

Applications:

IHC

Background:

E3 ubiquitin-protein ligase SMURF2?is an?enzyme?that in humans is encoded by the?SMURF2?gene. E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF