KRT6A/KRT6B/KRT6C Antibody

Catalog Number:

37107

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P02538
Gene ID:3853

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human KRT6A/KRT6B/KRT6C

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

Anti-KRT6A/KRT6B/KRT6C rabbit polyclonal antibody

Applications:

ELISA, IHC

Background:

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100
ELISA dilution: 1:1000-1:5000

Datasheet PDF