TOP1MT Antibody

Catalog Number:

37052

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q969P6
NCBI Gene ID: 116447
Gene Accssion: NP_001245375

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human topoisomerase (DNA) I, mitochondrial

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TOP1MT protein.

Applications:

IHC

Background:

This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

References:

appl_detail:

Immunohistochemistry: 1:15-1:50

Datasheet PDF