SOCS7 Antibody

Catalog Number:

37039

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O14512
NCBI Gene ID: 30837
Gene Accssion: NP_055413

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human suppressor of cytokine signaling 7

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SOCS7 protein.

Applications:

IHC

Background:

The protein as regulator signaling cascades probably through protein ubiquitination and/or sequestration. It plays an important role in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF