SPRN Antibody

Catalog Number:

37026

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q5BIV9
NCBI Gene ID: 503542
Gene Accssion: NP_001012526

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human shadow of prion protein homolog (zebrafish)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SPRN protein.

Applications:

IHC

Background:

SPRN (shadow of prion protein), also known as SHO or SHADOO, is a 151 amino acid cytoplasmic protein that is mainly expressed in brain. SPRN is considered a prion-like protein that has PrP(C)-like neuroprotective activity and may act as a modulator for the biological actions of normal and abnormal PrP. In humans, mutations in the gene encoding SPRN may be associated with variant and sporadic Creutzfeldt-Jakob disease, a degenerative neurological disorder that is incurable and invariably fatal.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF