LRPAP1 Antibody

Catalog Number:

36959

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P30533
NCBI Gene ID: 4043
Gene Accssion: NP_002328

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human low density lipoprotein receptor-related protein associated protein 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total LRPAP1 protein.

Applications:

WB IHC

Background:

Low density lipoprotein receptor-related protein associated protein 1?also known as?LRPAP1?or?RAP?is a chaperone?protein?which in humans is encoded by the LRPAP1?gene. LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all know ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Datasheet PDF