LRP5 Antibody

Catalog Number:

36957

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O75197
NCBI Gene ID: 4041
Gene Accssion: NP_002326

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human low density lipoprotein receptor-related protein 5

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total LRP5 protein.

Applications:

IHC

Background:

This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF