PAFAH1B1 Antibody

Catalog Number:

36952

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P43034
NCBI Gene ID: 5048
Gene Accssion: NP_000421

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PAFAH1B1 protein.

Applications:

IHC

Background:

This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF