GAD2 Antibody

Catalog Number:

36879

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q05329
NCBI Gene ID: 2572
Gene Accssion: NP_000809

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total GAD2 protein.

Applications:

IHC

Background:

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF