DUSP8 Antibody

Catalog Number:

36848

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q13202
NCBI Gene ID: 1850
Gene Accssion: NP_004411

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human dual specificity phosphatase 8

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total DUSP8 protein.

Applications:

WB IHC

Background:

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200

Datasheet PDF