DXT1 Antibody

Catalog Number:

36825

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q86Y01
NCBI Gene ID: 1840
Gene Accssion: NP_004407

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human deltex homolog 1 (Drosophila)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total DXT1 protein.

Applications:

IHC

Background:

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene. Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. DTX1 has been shown to interact with EP300. Functions as an ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF