HSD11B2 Antibody

Catalog Number:

37634

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P80365
NCBI Gene ID: 3291
Gene Accssion: NP_000187

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human hydroxysteroid (11-beta) dehydrogenase 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HSD11B2 protein.

Applications:

IHC

Background:

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.?

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF