RRAD Antibody

Catalog Number:

37229

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P55042
NCBI Gene ID: 6236
Gene Accssion: NP_004156.1

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human Ras-related associated with diabetes

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RRAD protein.

Applications:

IHC

Background:

The protein may be important in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. As regulator of voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway and phosphorylation and activation of CAMK2D. Mostly expressed in the heart and muscle of type II diabetic humans. Also found in the skeletal muscle, lung and adipose tissue. Lesser amounts in placenta and kidney.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF