SMG8 Antibody

Catalog Number:

37142

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8ND04
NCBI Gene ID: 55181
Gene Accssion: NP_060619

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human SMG8 nonsense mediated mRNA decay factor

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SMG8 protein.

Applications:

IHC

Background:

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF