CTLA4 Antibody

Catalog Number:

36808

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P16410
NCBI Gene ID: 1493
Gene Accssion: NP_005205

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human Cytotoxic T-lymphocyte protein 4

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CTLA4 protein.

Applications:

IHC

Background:

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF