IAPP Antibody

Catalog Number:

36738

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P10997
NCBI Gene ID: 3375
Gene Accssion: NP_000406

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human Islet amyloid polypeptide

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total IAPP protein.

Applications:

WB IHC

Background:

Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1:10-1:50

Datasheet PDF