PHLPP1 Antibody

Catalog Number:

36693

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O60346
NCBI Gene ID: 23239
Gene Accssion: BC014927/O60346

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human PH domain and leucine rich repeat protein phosphatase 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PHLPP1 protein.

Applications:

IHC

Background:

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF