PMAIP1 Antibody

Catalog Number:

36657

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q13794
NCBI Gene ID: 5366
Gene Accssion: BC032663/Q13794

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Full length fusion protein

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PMAIP1 protein.

Applications:

IHC

Background:

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1?By similarity. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.?

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF