PPP1R12A Antibody

Catalog Number:

36628

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O14974
NCBI Gene ID: 4659
Gene Accssion: BC111752/O14974

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human protein phosphatase 1, regulatory subunit 12A

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PPP1R12A protein.

Applications:

WB IHC

Background:

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC.

References:

appl_detail:

Western blotting: 1:1000-1:5000
Immunohistochemistry: 1:25-1:100

Datasheet PDF