PLEKHG6 Antibody

Catalog Number:

36627

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q3KR16
NCBI Gene ID: 55200
Gene Accssion: BC105961/Q3KR16

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human pleckstrin homology domain containing, family G (with RhoGef domain) member 6

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total PLEKHG6 protein.

Applications:

WB IHC

Background:

PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:100-1:300

Datasheet PDF