TAB1 Antibody

Catalog Number:

36598

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q15750
NCBI Gene ID: 10454
Gene Accssion: BC050554

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human TGF-beta activated kinase 1/MAP3K7 binding protein 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TAB1 protein.

Applications:

WB IHC

Background:

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1:100-1:300

Datasheet PDF