DNAJA1 Antibody

Catalog Number:

36538

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P31689
NCBI Gene ID: 3301
Gene Accssion: BC008182/P31689

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to a region derived from internal residues of human DnaJ (Hsp40) homolog, subfamily A, member 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total DNAJA1 protein.

Applications:

WB IHC

Background:

DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:100-1:300

Datasheet PDF