HSD3B7 Antibody

Catalog Number:

36537

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9H2F3
NCBI Gene ID: 80270
Gene Accssion: BC004929/Q9H2F3

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the N terminal of human hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HSD3B7 protein.

Applications:

WB IHC

Background:

This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Datasheet PDF