ELAC2 Antibody

Catalog Number:

36441

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9BQ52
NCBI Gene ID: 60528
Gene Accssion: BC001939

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human elaC ribonuclease Z 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ELAC2 protein.

Applications:

WB IHC

Background:

The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200

Datasheet PDF