RBBP8 Antibody

Catalog Number:

36376

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q99708
NCBI Gene ID: 5932
Gene Accssion: BC030590

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human retinoblastoma binding protein 8

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RBBP8 protein.

Applications:

IHC

Background:

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

References:

appl_detail:

Immunohistochemistry: 1:100-1:300

Datasheet PDF